Adrenergic Stimulation of Renin Secretion in the Isolated Perfused Rat Kidney

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Adrenergic Stimulation of Renin Secretion in the Isolated Perfused Rat Kidney

To avoid complicating systemic effects, the influence of adrenergic hormones on renin secretion was examined in the isolated rat kidney perfused with Krebs-dextran solution at a constant mean pressure and flow rate. Isoproterenol and glucagon produced a consistent increase in renin secretion without a change in perfusion pressure and flow. Similarly the increase in renin secretion with norepine...

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Andrenergic stimulation of renin secretion in the isolated perfused rat kidney.

To avoid complicating systemic effects, the influence of adrenergic hormones on renin secretion was examined in the isolated rat kidney perfused with Krebs-dextran solution at a constant mean pressure and flow rate. Isoproterenol and glucagon produced a consistent increase in renin secretion without a change in perfusion pressure and flow. Similarly the increase in renin secretion with norepine...

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The inhibition of renin secretion by alpha-adrenergic stimulation in the isolated rat kidney.

1. The respective role of alpha-adrenergic and beta-adrenergic receptors in mediating the effect of catecholamines on renin secretion was examined in the isolated perfused rat kidney. 2. Noradrenaline, which has combined alphaand beta-adrenergic activity, stimulated renin secretion only in the presence of the alpha-receptor blocking agent phenoxybenzamine. This stimulatory effect was largely pr...

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Differential response of renin secretion to vasoconstrictors in the isolated perfused rat kidney.

1. We have examined whether an increase of renal vascular resistance is generally accompanied by an inhibition of renin secretion. The effects of vasoconstriction produced by angiotensin II (Ang II), arginine-vasopressin (AVP), and potassium (KCl) depolarization on vascular resistance and on renin release from isolated rat kidneys perfused at constant pressure of 100 mmHg were investigated. 2. ...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1973

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.32.2.290